M. Bonta, S. Török, B. Döme, A. Limbeck:
"Tandem LA-LIBS Coupled to ICP-MS for Comprehensive Analysis of Tumor Samples";
Elemental imaging is regarded as a valuable approach for a wide application range in mod-ern medicine. Using tandem laser-ablation laser-induced breakdown spectroscopy (LA-LIBS) coupled to inductively coupled plasma-mass spectrometry (ICP-MS), high-sensitivity detec-tion of trace metals can be combined with the possibility of analyzing nonmetallic bulk com-ponents of biological samples (for example, carbon, hydrogen, and oxygen). In this work, the applicability of the tandem LA-LIBS approach for the laterally resolved elemental analysis of a mouse model tumor sample after administering cytostatic medication is demonstrated. Results show that trace elements can be detected using the LA-ICP-MS domain of the setup while major components of the samples are analyzed simultaneously using LIBS. By expand-ing the analyte range covered during one analysis, information could be extracted from the data set that is not accessible to either of the stand-alone analysis methods.
Biological tissues, LA-ICP-MS, trace elements, imaging
Erstellt aus der Publikationsdatenbank der Technischen Universitšt Wien.