[Zurück]

C. Jochum, C. N. Likos, N. Adzić, G. Kahl:
"Structure and stimuli-responsiveness of all-DNA den drimers: theory and experiment";
Vortrag: CECAM Workshop: Charged Species in Bulk and Interfaces: Mobility and Motility of Macromolecular Systems, Wien (eingeladen); 24.09.2018 - 27.09.2018; in: "Charged Species in Bulk and Interfaces: Mobility and Motility of Macromolecular Systems", (2018), S. 17 - 18.

Structure and stimuli-responsiveness of all-DNA dendrimers: theory and experiment:

We present a comprehensive theoretical and experimental study of the solution phase properties of DNA-based family of nanoparticles - dendrimer-like DNA molecules (DL-DNA) [1]. These charged DNA dendrimers are novel macromolecular aggregates, which hold high promise in targeted self-assembly of soft matter systems in the bulk and at interfaces. To describe the behavior of this
family of dendrimers, we use a theoretical model in which base-pairs of a single DL-DNA molecule are modeled by charged monomers, whose interactions are chosen to mimic the equilibrium
properties of DNA correctly. Experimental results on the sizes and conformations of DL-DNA are based on static and dynamic light scattering; at the same time, Molecular Dynamics simulations
are employed to model the equilibrium properties of DL-DNA, which compare favorably with the findings from experiments while at the same time providing a host of additional information and
insight into the molecular structure of the nanostructures. We also examine the salt-responsiveness of these macromolecules. The study of these charged dendrimer systems is an important field of research
in the area of soft matter due to their potential role for various interdisciplinary applications, ranging from molecular cages and carriers for drug delivery in a living organism [2] to the development of dendrimer-and dendron-based ultra-thin films in the area of nanotechnology [3].

These findings are essential to determine if DL-DNA is a viable candidate for the experimental realization of cluster crystals in the bulk, a novel form of solids with multiple site occupancy [4].

References:
[1] Y. Li, Y. Tseng and D. Luo, Nat. Mater. 3 38-42 (2004)
[2] C. Lee, J. MacKay, J. Fréchet and F. Szoka, Nat. Biotechnol. 23 1517-1526 (2005)
[3] D. Tully and J. Fréchet, Chem. Commun. 14 1229-1239 (2001)
[4] B. Mladek, M. Neumann, G. Kahl and C. Likos, Phys. Rev. Lett. 96 045701 (2006)

https://publik.tuwien.ac.at/files/publik_271759.pdf

Projektleitung Gerhard Kahl:
DFS