Publications in Scientific Journals:

A. Renner, I. Rausch, J. Gonzalez, I. Navarro de Lara, J. Sieg, E. Laistler, M. Glanzer, D. Dungl, E. Moser, T. Beyer, M. Figl, W. Birkfellner:
"A head coil system with an integrated orbiting transmission point source mechanism for attenuation correction in PET/MRI";
Physics in Medicine and Biology, 63 (2018), 22; 22501401 - 22501414.

English abstract:
The combination of positron emission tomography (PET) and magnetic resonance imaging (MRI)
provides a benefit for diagnostic imaging. Still, attenuation correction (AC) is a challenge in PET/
MRI compared to stand-alone PET and PET-computed tomography (PET/CT). In the absence of
photonic transmission sources, AC in PET/MRI is usually based on retrospective segmentation
of MR images or complex additional MR-sequences. However, most methods available today are
still challenged by either the incorporation of cortical bone or substantial anatomical variations of
subjects. This leads to a bias in quantification of tracer concentration in PET. Therefore, we have
developed a fully integrated transmission source system for PET/MRI of the head to enable direct
measurement of attenuation coefficients using external positron emitters, which is the reference
standard in AC. Based on a setup called the `liquid driveŽ presented by Jones et al (1995) two decades
ago, we built a head coil system consisting of an MR-compatible hydraulic system driving a point
source on a helical path around a 24-channel MR-receiver coil to perform a transmission scan.
Sinogram windowing of the moving source allows for post-injection measurements. The prototype
was tested in the Siemens Biograph mMR using a homogeneous water phantom and a phantom
with air cavities and a Teflon (PTFE) cylinder. The second phantom was measured both with and
without emission activity. For both measurements air, water and Teflon were clearly distinguishable
and homogeneous regions of the phantom were successfully reproduced in the AC map. For water
the linear attenuation coefficient was measured as (0.096 ± 0.005) cm−1 in accordance with the true
physical value. This combined MR head coil and transmission source system is, to our knowledge, the
first working example to use an orbiting point source in PET/MRI and may be helpful in providing
fully-quantitative PET data in neuro-PET/MRI.

PET, PET/MRI, hybrid imaging, attenuation correction, transmission scan, post-injection

Created from the Publication Database of the Vienna University of Technology.