Publications in Scientific Journals:

K. Seidler, K. Ehrmann, P. Steinbauer, A. Rohatschek, O.G. Andriotis, C. Dworak, T. Koch, H. Bergmeister, C. Grasl, H. Schima, P.J. Thurner, R. Liska, S. Baudis:
"A structural reconsideration: Linear aliphatic or alicyclic hard segments for biodegradable thermoplastic polyurethanes?";
Journal of Polymer Science Part A: Polymer Chemistry, 56 (2018), 19; 2214 - 2224.

English abstract:
Thermoplastic polyurethane elastomers (TPUs) with
a biodegradable chain extender and different nonaromatic diiso-
cyanate hard segments were synthesized and tested concerning
their thermal, mechanical, and degradation properties and for
their processability regarding electrospinning. The design of the
TPUs was based on the structural modification of the hard seg-
ment using linear aliphatic hexamethylene diisocyanate (HMDI),
more rigid alicyclic 4,4'-methylene bis(cyclohexylisocyanate)
(H12MDI), 1,3-bis(isocyanatomethyl)cyclohexane (BIMC), or iso-
phorone diisocyanate (IPDI). The soft segment consisted of
poly(tetrahydrofuran). Bis(2-hydroxyethyl) terephthalate (BET)
was used as chain extender with cleavable ester bonds. Some
of the polyurethanes based on alicyclic diisocyanate showed
better mechanical performance than the less rigid HMDI-based
TPU. The TPU in vitro degradability was tested for 25 days at
elevated temperatures in PBS buffer and indicated a bulk ero-
sion process. Electrospinning experiments were conducted and
promising results with respect to further applicability of these
materials in vascular tissue engineering were obtained.

biodegradable; electrospinning; nontoxic; thermo- plastic polyurethane; vascular grafts

"Official" electronic version of the publication (accessed through its Digital Object Identifier - DOI)

Electronic version of the publication:

Created from the Publication Database of the Vienna University of Technology.