Zeitschriftenartikel:
N. Kratena, S. Pilz, M. Weil, G. Gmeiner, V. Enev, P. Gärtner:
"Synthesis and structural elucidation of a dehydrochloromethyltestosterone metabolite";
Organic & Biomolecular Chemistry,
-
(2018),
16;
S. 2508
- 2521.
Kurzfassung englisch:
The human urinary long-term metabolite "M3" (4-chloro-17β-hydroxymethyl-17α-methyl-18-norandrost-13-en-3-ol) of the common doping agent DHCMT has thus far been detected via GC/MS-MS, creating ambiguities concerning its absolute configuration. Its structure was elucidated via the synthesis of all eight possible stereoisomers with 17β-hydroxymethyl configuration. The highlights of the synthesis consist of a novel first generation approach to 4β-chloro-5β compounds as well as a divergent route which allows easy access to the remaining A-ring chlorohydrins.
"Offizielle" elektronische Version der Publikation (entsprechend ihrem Digital Object Identifier - DOI)
http://dx.doi.org/10.1039/C8OB00122G
Erstellt aus der Publikationsdatenbank der Technischen Universität Wien.