[Zurück]

M.-H. Chien, M. Brameshuber, B. Rossboth, G. Schütz, S. Schmid:
"Single-molecule optical absorption imaging by nanomechanical photothermal sensing at room temperature";
Poster: Eurosensors 2018, Graz; 09.09.2018 - 12.09.2018; in: "Proceedings Eurosensors 2018", MDPI, Volume 2 (2018), ISSN: 2504-3900.

In present study, a novel nanomechanical absorption-based microscopy with unprecedented sensitivity of 16
fW/Hz1/2 and position accuracy of 30 nm is introduced with silicon nitride drum resonator. The imaging of
nanoparticles with diameter of 10 nm - 200 nm and single molecules is demonstrated. A systematic discussion
on the optimization of sensitivity by stress engineering is also performed both experimentally and
theoretically. With the applicability, 5-order-of-magnitudes higher sensitivity comparing with the
state-of-the-art detection scheme, and outstanding spatial resolution, this study provides a simple alternative
for qualitative and quantitative analysis and imaging of single molecules without labeling, which could
potentially unveil the underlying nanoscale dynamics as well as providing a new robust microscopy with high
precision and accuracy.