Zeitschriftenartikel:
P. Schaaf, V. Gojic, T. Bayer, F. Rudroff, M. Schnürch, M.D. Mihovilovic:
"Easy Access to Enantiopure (S)- and (R)-Aryl Alkyl Alcohols by a Combination of Gold(III)-Catalyzed Alkyne Hydration and Enzymatic Reduction";
ChemCatChem,
10
(2018),
S. 920
- 924.
Kurzfassung englisch:
Chemoenzymatic one-pot processes based on the combination of metal catalysis and biocatalysis open up highly attractive perspectives regarding the production of enantiopure compounds. By combining a gold-catalyzed hydration reaction with an enzymatic reduction, we present a straightforward and atom-economical chemoenzymatic method for the synthesis of secondary alcohols with excellent optical purity. Efficient cofactor recycling exploits the solvent of the metal-catalyzed step as an auxiliary substrate for the enzymatic step.
"Offizielle" elektronische Version der Publikation (entsprechend ihrem Digital Object Identifier - DOI)
http://dx.doi.org/10.1002/cctc.201701752
Erstellt aus der Publikationsdatenbank der Technischen Universität Wien.