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Publications in Scientific Journals:

N. Iqbal, J.D. Stewart, P. Macheroux, F. Rudroff, M.D. Mihovilovic:
"Novel concurrent redox cascades of (R)- and (S)-carvones enables access to carvo-lactones with distinct regio- and enantioselectivity";
Tetrahedron, 52 (2018), 74; 7389 - 7394.



English abstract:
Within this study, we investigated a one-pot enzymatic redox cascade composed of different enoate reductases (5 EREDs from diverse bacterial origins) and various Baeyer-Villiger monooxygenases (4 BVMOs) with complementary regioselectivity that enabled access to six out of eight carvo-lactone stereoisomers starting from readily available natural carvones. Applicability of this two-step cascade was demonstrated by preparative scale experiments yielding up to 76% of the desired chiral carvolactone.


"Official" electronic version of the publication (accessed through its Digital Object Identifier - DOI)
http://dx.doi.org/10.1016/j.tet.2018.11.005


Created from the Publication Database of the Vienna University of Technology.