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E. Gasparotto, D. Ret, S. Knaus, E. Untersmayr, A. Dadra, N. Samadi:
"Sialic Acid of Caco2 Cells: analysis and modifications of glycan surface";
Vortrag: 23rd Austrian Carbohydrate Workshop, Graz University of Technology; 14.02.2019 - 15.02.2019.

Since many years the important connection between glycosylation pattern on cell surfaces, immune system and its involvement in many cell events is known. In fact, the wide composition of many different sugars that decorate proteins and lipids on cell surface as glycocalyx highly affects the cell outcome playing an important role in cell-cell interaction, signaling, development and in the "self" recognition. The change in the specific sugar profile is consequently related to infections, autoimmune diseases and cancer income. Within all this kind of sugars, l´N-5-GlycolylNeuraminic Acid recently has raised the interest of researchers as a foreign sugar introduced in human organism by dietary intake which is related to immunogenic reaction and chronic inflammatory diseases.
The aim of this study is better understand how sugars, especially Neu5Gc, affect glycan composition on cell surface and the connection between glycosylation pattern change and immune system reaction. We are particularly interested to study which kind of mechanism could be involved in the activation of immune system after Neu5Gc intake and if it is related to the outbreak of cancer or some important autoimmune diseases.

glycosylation pattern on cell surfaces, immune system, different sugars, cell-cell interaction, signaling, development and in the "self" recognition