[Zurück]

M.-H. Chien, M. Brameshuber, B. Rossboth, G. Schütz, S. Schmid:
"Single-molecule Optical Absorption Imaging by Nanomechanical Photothermal Sensing at Room Temperature";
Vortrag: Single-Molecule Sensors and NanoSystems International Conference - S3IC 2019, München; 03.04.2019 - 05.04.2019.

A novel nanomechanical absorption-based microscopy with unprecedented sensitivity
of 16 fW/Hz1/2 and position accuracy of 30 nm is introduced with silicon nitride drum resonator.
[1] The imaging of nanoparticles with diameter of 10 nm - 200 nm and single molecules is
demonstrated. A systematic discussion on the optimization of sensitivity by stress engineering is
also performed both experimentally and theoretically. With the applicability, 5-order-ofmagnitudes
higher sensitivity comparing with the state-of-the-art detection scheme, and
outstanding spatial resolution, this study provides a simple alternative for qualitative and
quantitative analysis and imaging of single molecules without labeling, which could potentially
unveil the underlying nanoscale dynamics as well as providing a new robust microscopy with high
precision and accuracy.