Zeitschriftenartikel:
J. Aronow, C. Stanetty, I. Baxendale, M.D. Mihovilovic:
"Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing";
Monatshefte für Chemie,
150
(2019),
1;
S. 11
- 19.
Kurzfassung englisch:
Abstract: A continuous flow procedure for the synthesis of methyl glycosides (Fischer glycosylation) of various monosaccharides using a heterogenous catalyst has been developed. In-depth analysis of the isomeric composition was undertaken and high consistency with corresponding results observed under microwave heating was obtained. Even in cases where addition of water was needed to achieve homogeneity-a prerequisite for the flow experiments-no detrimental effect on the conversion was found. The scalability was demonstrated on a model case (mannose) and as part of the target-oriented synthesis of D-glycero-D-manno heptose, both performed on multigram scale.
"Offizielle" elektronische Version der Publikation (entsprechend ihrem Digital Object Identifier - DOI)
http://dx.doi.org/10.1007/s00706-018-2306-8
Zugeordnete Projekte:
Projektleitung Christian Stanetty:
Kontrollierter Zuckerabbau durch N-Heterocyclische Carbene
Erstellt aus der Publikationsdatenbank der Technischen Universität Wien.