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L. Taghizadeh, A. Karimi, E. Presterl, C. Heitzinger:
"Bayesian inversion for a biofilm model including quorum sensing";
Computers in Biology and Medicine, 117 (2020), 103582.

We propose a mathematical model based on a system of partial differential equations (PDEs) for biofilms. This model describes the time evolution of growth and degradation of biofilms which depend on environmental factors. The proposed model also includes quorum sensing (QS) and describes the cooperation among bacteria when they need to resist against external factors such as antibiotics. The applications include biofilms on teeth and medical implants, in drinking water, cooling water towers, food processing, oil recovery, paper manufacturing, and on ship hulls. We state existence and uniqueness of solutions of the proposed model and implement the mathematical model to discuss numerical simulations of biofilm growth and cooperation. We also determine the unknown parameters of the presented biofilm model by solving the corresponding inverse problem. To this end, we propose Bayesian inversion techniques and the delayed-rejection adaptive-Metropolis (DRAM) algorithm for the simultaneous extraction of multiple parameters from the measurements. These quantities cannot be determined directly from the experiments or from the computational model. Furthermore, we evaluate the presented model by comparing the simulations using the estimated parameter values with the measurement data. The results illustrate a very good agreement between the simulations and the measurements.

Partial differential equation, Growth and degradation of biofilms, Quorum sensing, Existence and uniqueness, Inverse problem, Bayesian inversion, Uncertainty quantification

http://dx.doi.org/10.1016/j.compbiomed.2019.103582