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M. Braunisch, C. Mayer, A. Bauer, G. Lorenz, B. Haller, K. Rizas, S. Hagmair, L. von Stülpnagel, W. Hamm, R. Günther, S. Angermann, J. Matschkal, S. Kemmner, A. Hasenau, I. Zöllinger, D. Steubl, J. F. Mann, T. Lehnert, J. Scherf, J. Braun, P. Moog, C. Küchle, L. Renders, M. Malik, G. Schmidt, S. Wassertheurer, U. Heemann, C. Schmaderer:
"Cardiovascular Mortality Can Be Predicted by Heart Rate Turbulence in Hemodialysis Patients";
Frontiers in Physiology, 11 (2020), 77; 11 pages.

Background: Excess mortality in hemodialysis patients is mostly of cardiovascular origin. We examined the association of heart rate turbulence (HRT), a marker of baroreflex sensitivity, with cardiovascular mortality in hemodialysis patients.

Methods: A population of 290 prevalent hemodialysis patients was followed up for a median of 3 years. HRT categories 0 (both turbulence onset [TO] and slope [TS] normal), 1 (TO or TS abnormal), and 2 (both TO and TS abnormal) were obtained from 24 h Holter recordings. The primary end-point was cardiovascular mortality. Associations of HRT categories with the endpoints were analyzed by multivariable Cox regression models including HRT, age, albumin, and the improved Charlson Comorbidity Index for hemodialysis patients. Multivariable linear regression analysis identified factors associated with TO and TS.

heart rate turbulence, cardiovascular mortality; baroreflex; mortality risk prediction; hemodialysis

http://dx.doi.org/10.3389/fphys.2020.00077