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A. Khanmohammadi, A. Aghaie, E. Vahedi, A. Qazvini, M. Ghanei, A. Afkhami, A. Hajian, H. Bagheri:
"Electrochemical biosensors for the detection of lung cancer biomarkers: A review";
Talanta, 206 (2020), 1 - 14.

Cancer is one of the most widespread challenges and important diseases, which has the highest mortality rate.
Lung cancer is the most common type of cancer, so that about 25% of all cancer deaths are related to the lung
cancer. The lung cancer is classified as two different types with different treatment methodology: the small cell
lung carcinoma and nonsmall cell lung carcinoma are two categories of the lung cancer. Since the lung cancer is
often in the latent period in its early stages, therefore, early diagnosis of lung cancer has many challenges.
Hence, there is a need for sensitive and reliable tools for preclinical diagnosis of lung cancer. Therefore, many
detection methods have been employed for early detection of lung cancer. As lung cancer tumors growth in the
body, the cancerous cells release numerous DNA, proteins, and metabolites as special biomarkers of the lung
cancer. The levels of these biomarkers show the stages of the lung cancer. Therefore, detection of the biomarkers
can be used for screening and clinical diagnosis of the lung cancer. There are numerous biomarkers for the lung
cancer such as EGFR, CEA, CYFRA 21-1, ENO1, NSE, CA 19-9, CA 125 and VEGF. Nowadays, electrochemical
methods are very attractive and useful in the lung cancer detections. So, in this paper, the recent advances and
improvements (2010-2018) in the electrochemical detection of the lung cancer biomarkers have been reviewed.

http://dx.doi.org/10.1016/j.talanta.2019.120251