[Zurück]

R. Reichsöllner, A. Puljic, K. Ehrmann, J. Hackethal, H. Redl, S. Baudis:
"Gelatin Photo-Hydrogels as Material Platform for Tissue Regeneration";
Poster: 11th World Biomaterials Congress, Hampshire, United Kingdom, online; 11.12.2020 - 15.12.2020; in: "11th World Biomaterials Congress", WBC2020LATE-4406 (2020), S. 1.

Regenerative therapies to treat the loss of tissue, incl. soft tissue (e.g. skin reconstruction after trauma or circulation disorders), and hard tissue (e.g. alveolar reconstruction prior dental implantation) is predominantly based on tissue augmentation. Here, implants provide a suitable matrix as scaffold for the growth of new tissue to replace the temporary construct. However, for the regeneration of large tissue defects, neovascularization of such implants is prerequisite. For this reason it is necessary to stimulate the formation of vascular networks within these constructs. Photocrosslinkable hydrogels are a promising material platform for this approach. In this study, we employ hydrogels, based on different gelatin (Gel) modifications, incl. Gel-norbornene (Gel-NB) [1] and Gel-allyl glycidyl ether (Gel-AGE) [2], which can be crosslinked in situ, via photopolymerization. This enables the fabrication of complex structures either by extrusion based 3D printing (i.e. bioprinting, in the µm to cm regime) or by two-photon polymerization (2PP, in the nm to mm regime)

3D bioprinting/biofabrication, Biopolymeric biomaterials, Hydrogels for TE applications