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B. Lendl, K. Wieland:
"In-line ultrasound-enhanced Raman spectroscopy";
Art der Veröffentlichung: Webinar, Projekt: https://lp.constantcontactpages.com/su/EG3873f/InLineUltraSoundRaman; 2020.

Raman spectroscopy is a non-destructive characterization tool for gaseous, liquid and solid samples. However, the low cross-section of inelastically (Raman) scattered light imposes a major drawback for in-line process control in terms of sensitivity. Leveraging ultrasonic particle manipulation combined with in-line Raman spectroscopy, an add-on for Raman probes was designed to overcome this limitation. The final prototypes feature two different geometries and are fabricated out of 1.4404 stainless steel to fit a D25 Ingold port ensuring FDA-compatibility for unrestricted use in process analytical technology (PAT). The geometrical arrangement of acoustic wave and Raman laser propagation ensures particle concentration in the focus of the Raman probe increasing the Raman sensitivity by a factor of ≈ 30. The audience will also be introduced to a refined geometry which adds selectivity to in-line Raman sensing as it allows to either investigate the liquid or solid phase of stirred suspensions. The webinar will end with a few applications examples showcasing the performance of ultrasound enhanced Raman spectroscopy in a process analytical setting.

Raman spectroscopy, Ultrasonic particle manipulation, In-line monitoring, Stirred suspensions

https://publik.tuwien.ac.at/files/publik_294650.pdf