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A.N. Gusev, Y. Baluda, E. Braga, M. Kryukova, M. Kiskin, E. Chuyan, M. Ravaeva, I. Cheretaev, W. Linert:
"Mn(II), Co(II), Ni(II) and Zn salicylates: synthesis, structure and biological properties studies";
Inorganica Chimica Acta, 528 (2021), 120606 - 120613.

Reaction of acetylsalicylic acid (aspirin) (H2L) with Mn(II), Co(II), Ni(II) and Zn acetates allow to obtain salicylates of related metals. The solid-state structures of prepared complexes were determined by single crystal X-ray crystallography and spectroscopic techniques. Zinc, nickel and cobalt(II) complexes are mononuclear and their crystal structures composed of neutral discrete molecules [Zn(sal)2(H2O)2], [Ni(sal)2(H2O)4] and [Co(sal)2(H2O)4] while manganese derivative has 2D polymeric structure. The cardiorespiratory and skin microcirculation activity of these metal complexes was evaluated. Particularly, the promising therapeutic activities displayed by 1-4 complexes make them potential candidates for the development of a promising drugs.

Metal complexes, aspirin, salicylate, X-ray crystallography microcirculation activity, cardiorespiratory system.

http://dx.doi.org/10.1016/j.ica.2021.120606