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P. Schwarzl, K. Ehrmann, C. Grasl, H. Bergmeister, H. Schima, B. Podesser, R. Liska, S. Baudis:
"Enhanced Mechanical Properties of Hard-Block Degradable Thermoplastic Polyurethanes for Vascular Tissue Regeneration";
Vortrag: TERMIS 6th World Congress, Maastricht, Niederlande; 15.11.2021 - 19.11.2021; in: "Book of Abstract", (2021).

Introduction Biodegradable scaffolds for tissue engineering are getting more and more important, including vascular grafts with small-diameter.1 It is often reported, that materials like thermoplasts show good degradation behaviour. In contrast to that the mechanical properties are not sufficient for the intended application. Here, we introduced new hard-block degradable thermoplastic polyurethanes (TPUs) based on a variety of cleavable chain-extenders.2-4 These new materials provide new insights especially on the improvement of mechanical properties for thermoplasts. Methods TPUs, based on new developed cleavable chain-extenders, were processed via electrospinning, resulting in highly-porous tubes.2-4 The material itself was characterized in terms of biomechanical properties, degradability, biocompatibility and were tested in vivo. Results Different hard-block degradable TPUs were prepared by varying the hard-block components and by adjusting the ratio of these. These novel materials were compared in terms of mechanical properties, degradability and biocompatibility. There is a wide consensus that the mechanical properties are controlled by the hard-blocks and therefore by the choice of isocyanate and chain-extender. Since most biodegradable TPU concepts are based on ester-cleavage of soft-blocks, this concept was adapted for hard-block degradable TPUs by integration of cleavable chain-extenders. Furthermore, the mechanical properties of the materials were improved by introducing moieties, which also have the ability to form strong microcrystalline structures.

Biodegradable scaffolds for tissue engineering, thermoplasts, good degradation behaviour, mechanical properties, new hard-block degradable thermoplastic polyurethanes, improvement of mechanical properties

https://termis.org/wc2021/final-program