Zeitschriftenartikel:
D. Schwendenwein, A. Ressmann, M. Entner, V. Savic, M. Winkler, F. Rudroff:
"Chemo-enzymatic cascade for the generation of fragrance aldehydes";
Catalysts,
11
(2021),
8;
8 S.
Kurzfassung englisch:
In this study, we present the synthesis of chiral fragrance aldehydes, which was tackled by a combination of chemo-catalysis and a multi-enzymatic in vivo cascade reaction and the devel-opment of a highly versatile high-throughput assay for the enzymatic reduction of carboxylic acids. We investigated a biocompatible metal-catalyzed synthesis for the preparation of α or β substituted cinnamic acid derivatives which were fed directly into the biocatalytic system. Subsequently, the target molecules were synthesized by an enzymatic cascade consisting of a carboxylate reduction, followed by the selective C-C double bond reduction catalyzed by appropriate enoate reductases. We investigated a biocompatible oxidative Heck protocol and combined it with cells expressing a carboxylic acid reductase from Neurospora crassa (NcCAR) and an ene reductase from Saccharomyces pastorianus for the production fragrance aldehydes.
Schlagworte:
Carboxylic acid reductase; Chemo-enzymatic cascade; Ene reductase; Fragrance aldehydes; Heck-coupling
"Offizielle" elektronische Version der Publikation (entsprechend ihrem Digital Object Identifier - DOI)
http://dx.doi.org/10.3390/catal11080932
Elektronische Version der Publikation:
https://publik.tuwien.ac.at/files/publik_303197.pdf
Erstellt aus der Publikationsdatenbank der Technischen Universität Wien.